Solutions & Applications
Discover how our rapid kinetics technology powers breakthrough research across diverse scientific disciplines.
Enzyme Kinetics
Comprehensive analysis of enzyme mechanisms, rate constants, and catalytic efficiency for biochemical research.
- Stopped-flow kinetics
- Quench-flow analysis
- Multi-substrate reactions
- Inhibition studies
Drug Discovery
Accelerate drug development with precise kinetic characterization of drug-target interactions and enzyme inhibition.
- IC50 determination
- Ki measurements
- Mechanism-based inhibition
- SAR studies
Protein Folding
Study protein folding dynamics, stability, and conformational changes with millisecond time resolution.
- Folding kinetics
- Unfolding studies
- Refolding analysis
- Stability assays
More Applications
Explore additional applications including ligand binding, nucleic acid kinetics, and biophysical studies.
- DNA/RNA kinetics
- Ligand binding
- Channel proteins
- Membrane transport
Featured Research Applications
See how researchers worldwide are using KinTek instruments to advance scientific discovery.
Enzyme Mechanism Studies
Detailed characterization of enzyme reaction mechanisms using stopped-flow spectroscopy.
Drug-Target Interactions
High-throughput screening of drug candidates against therapeutic targets.
Protein Folding Dynamics
Real-time monitoring of protein folding and unfolding processes.
Publications with KinTek
A selection of research publications that have utilized KinTek instruments and software.
| Title | Authors & Publication |
|---|---|
| Nucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase | Matthew W. Kellinger and Kenneth A. Johnson |
| Structural basis for mismatch surveillance by CRISPR–Cas9 | Jack P. K. Bravo, Mu-Sen Liu, et al. Nature volume 603, pages 343–347 (2022) |
| Kinetics of elementary steps in loop-mediated isothermal amplification (LAMP) show that strand invasion during initiation is rate-limiting | Tyler L Dangerfield, Inyup Paik, et al. Nucleic Acids Research, Volume 51, Issue 1, 2023 |
| Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication | Jack P.K. Bravo, Tyler L. Dangerfield, et al. |
| Rate-limiting Pyrophosphate Release by HIV Reverse Transcriptase Improves Fidelity | An Li, Shanzhong Gong, Kenneth A. Johnson |
| Pre-steady-state kinetic analysis of the mechanism of ATP hydrolysis by the Escherichia coli Rep helicase | Timothy M. Lohman, K. A. Johnson. Biochemistry 1986, 25, 1, 214–224 |
| A new mechanism for DNA polymerase selectivity | K. A. Johnson. Annual review of biochemistry 62 (1), 685-713 |
| Kinetic and thermodynamic analysis of the mechanism of RecA protein-promoted DNA strand exchange | S. C. Kowalczykowski, K. A. Johnson. Biochemistry 32 (33), 8469-8477 |
| The fidelity of DNA synthesis by the catalytic subunit of DNA polymerase III holoenzyme | M. F. Goodman, K. A. Johnson. Journal of Biological Chemistry 268 (3), 2124-2129 |
| A continuous fluorescence assay for monitoring DNA polymerization | S. J. Benkovic, K. A. Johnson. Analytical biochemistry 245 (2), 209-215 |
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